C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) C12N 1/20 (2006.01) C12N 15/00 (2006.01) C12N 15/54 (2006.01) C12N 15/63 (2006.01) C12N 15/74 (2006.01) C12P 21/00 (2006.01) C12P 21/04 (2006.01) C12Q 1/14 (2006.01) C12Q 1/18 (2006.01)
Patent
CA 2400509
The present invention relates to a recombinant organism, and a bacterial strain such as Staphylococcus, and S. aureus, in particular. The organism has a regulatable gene for encoding an RNA polymerase specificity factor required for expression of at least one gene essential for growth of the organism. The regulatable gene is one which is responsive to an exogenous effector molecule, and may in particular be an inducer-responsive gene including an operator site, such as a lac operator, to which a repressor, such as a lacl-encoded repressor, is capable of binding. The regulatable gene may in particular be an IPTG responsive plaC allele.
La présente invention concerne un organisme recombinant et un brin bactérien tel que Staphylococcus, en particulier S. aureus. L'organisme comporte un gène régulable destiné à coder un facteur de spécificité d'ARN polymérase nécessaire à l'expression d'au moins un gène essentiel à la croissance de l'organisme. Le gène régulable est un gène répondant à une molécule effectrice exogène, et peut en particulier être un gène répondant à un inducteur, comportant un site opérateur, tel qu'un opérateur lac, un répresseur tel qu'un répresseur codé par lacl pouvant se lier audit opérateur. Le gène régulable peut en particulier être un allèle plaC répondant à IPTG.
Carroll Patricia
Healy Judith M.
Thresher Jason
Wobbe C. Richard
Anadys Pharmaceuticals Inc.
Ridout & Maybee Llp
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