Regulated target expression for screening

Details Regulated target expression for screening Regulated target expression for screening

C - Chemistry, Metallurgy

12

Q

C12Q 1/04 (2006.01) C07H 21/04 (2006.01) C07K 14/245 (2006.01) C07K 14/31 (2006.01) C12N 1/12 (2006.01) C12N 1/14 (2006.01) C12N 1/20 (2006.01) C12N 9/06 (2006.01) C12N 9/10 (2006.01) C12N 9/24 (2006.01) C12N 9/78 (2006.01) C12N 9/90 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2325602

Methods and compositions for screening compounds for potential therapeutic activity and for identifying drug targets are provided. The methods rely on controlled expression (either underexpression or overexpression) of an essential cellular gene, which can be achieved, in one embodiment, by fusion of a heterologous regulatory element to the gene. The method is capable of identifying a drug target in the absence of any knowledge of target function.

L'invention porte sur des méthodes et compositions servant au criblage de composés pour ce qui est de leur activité thérapeutique potentielle et à l'identification de cibles de médicaments. Lesdites méthodes, qui reposent sur l'expression régulée (sous ou sur expression) d'un gène essentiel de culture, laquelle dans l'une des variantes s'obtient par la fusion avec le gène d'un élément régulateur hétérologue, permettent d'identifier des cibles de médicaments même sans en connaître aucune des fonctions.

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