C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A01H 5/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12N 9/16 (2006.01) C12N 9/24 (2006.01) C12N 15/55 (2006.01) C12N 15/82 (2006.01)
Patent
CA 2253348
The invention lies in the field of regulation of carbon flow in the metabolism of the cell. It has been found that induction of a change in the intracellular availability of the saccharide trehalose-6-phosphate (T-6- P) induces modifications of the development and/or composition of cells, tissue and organs in vivo. These changes can be induced by introducing or inhibiting the enzymes trehalose phosphate synthase (TPS) which is capable of forming T-6-P and trehalose phosphate phosphatase (TPP) which degrades T-6-P into trehalose. The carbon flow through the glycolysis will be stimulated by a decrease in the intracellular level of T-6-P.
L'invention appartient au domaine de la régulation de l'écoulement carbonique dans le métabolisme de la cellule. On a trouvé que l'induction d'un changement dans la disponibilité intracellulaire du saccharide tréhalose-6-phosphate (T-6-P) induisait in vivo des modifications dans le développement et/ou la composition de cellules, de tissu et d'organes. On peut induire ces changements par introduction ou par inhibition de l'enzyme tréhalose phosphate synthase (TPS), laquelle peut former T-6-P et la tréhalose phosphate phosphatase (TPP), laquelle dégrade T-6-P en tréhalose. L'écoulement carbonique par glycolyse peut être stimulé par une diminution du taux intracellulaire de T-6-P.
Goddijn Oscar Johannes Maria
Pen Jan
Smeekens Josephus Christianus Maria
Smits Maria Theresia
Gowling Lafleur Henderson Llp
Mogen International N.v.
Syngenta Mogen B.v.
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