Regulation of allergen induced gene

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61K 38/20 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2512808

A composition and method for alleviation of an allergic response by regulation of resistin-like molecules .alpha. or .beta.(RELM.alpha. or RELM.beta.) expression. RELMS are also disclosed as markers for assessment of an allergic patient's status, for example, monitoring inflammation and/or tissue repair in a lung or airway of an asthmatic patient. Regulation of RELMS is involved in the pathogenesis of allergic lung inflammation and other allergen-induced conditions. The discovery of the involvement of RELM.alpha. and RELM.beta. in the asthma mechanistically links the pathogenesis of insulin resistance and obesity, known to involve RELMS, with asthma.

La présente invention concerne une composition et un procédé pour réduire une réponse allergique par régulation de l'expression de molécules .alpha. ou .beta. de type résistine (RELM.alpha. ou RELM.beta.). Cette invention concerne également des RELM en tant que marqueurs permettant d'évaluer l'état d'un patient allergique, par exemple, de surveiller une inflammation et/ou une régénération tissulaire dans un poumon ou une voie aérienne d'un patient asthmatique. La régulation des RELM est impliquée dans la pathogenèse d'une inflammation pulmonaire allergique et d'autres pathologies induites par allergène. La découverte de l'implication de RELM.alpha. et RELM.beta. dans l'asthme lie de manière mécaniste la pathogenèse de la résistance à l'insuline et de l'obésité, connues pour impliquer RELM, à l'asthme.

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