A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61P 13/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2597794
The present invention discloses a role of CCN3 in diseases associated with the overexpression of CCN2, which include but are not limited to kidney disease, fibrosis, and cancer. The full length CCN3 protein or fragments thereof or isoforms (or combinations) of CCN3 are involved in these diseases. The isolated and purified CCN3 protein or its fragments or isoforms (or combinations) of CCN3 can be potentially used in the treatment or prevention of these diseases by regulating the expression and/or activity of the CCN2 protein. The level of CCN3 in tissue or body fluids can also be used to predict, diagnose and/or follow the progression of diseases as well as to determine the effectiveness of therapeutic intervention.
La présente invention a trait à un rôle de CCN3 dans des maladies associées à la surexpression de CCN2, comprenant mais de manière non limitative la maladie rénale, la fibrose, et le cancer. La protéine CCN3 pleine longueur ou ses fragments ou isoformes (ou des combinaisons) de CCN3 sont impliqués dans ces maladies. La protéine CCN3 isolée et purifiée ou ses fragments ou isoformes (ou des combinaisons) de CCN3 peuvent être utilisés potentiellement dans le traitement ou la prévention de ces maladies par la régulation de l'expression et/ou de l'activité de la protéine CCN2. Le niveau de CCN3 dans le tissu ou des liquides organiques peut également être utilisé pour la prédiction, le diagnostic et/ou le suivi de la progression des maladies ainsi que pour la détermination de l'efficacité d'intervention thérapeutique.
Oyen Wiggs Green & Mutala Llp
Rosalind Franklin University Of Medicine And Science
LandOfFree
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