Regulation of cell proliferation and differentiation using...

Details Regulation of cell proliferation and differentiation using... Regulation of cell proliferation and differentiation using...

C - Chemistry, Metallurgy

12

N

195/46, 167/103.

C12N 5/00 (2006.01) A61K 38/29 (2006.01) C07K 14/635 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 1326460

Abstract of the Disclosure Methods, including a method of inhibiting proliferation and enhancing differentiation of a mammalian cell involving bringing the cell into contact with a peptide which has 10% or greater homology with a region of human parathyroid hormone or human hypercalcemic factor and which is capable of enhancing the differentiation or inhibiting the proliferation in vitro of cultured human keratinocytes. Also disclosed is a method of inducing proliferation of a mammalian cell including bringing the cell into contact with a peptide which has 10% or greater homology with a region of human parathyroid hormone or human hypercalcemic factor and which is capable of blocking the inhibition of proliferation or stimulation of differentiation in vitro, of cultured human keratinocytes by PTH (1-34), 1,25(OH)2D3, or CFF (1-34).

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