Regulation of cell surface proteins

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) G01N 33/15 (2006.01) G01N 33/483 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2517186

The invention relates to methods of screening for compounds that regulate the activity of cell surface proteins. The present invention relates to a method for regulating the insertion or retention of a protein, such as the cystic fibrosis transmembrane conductance regulator (CFTR), in a cell surface membrane. The invention also relates to methods for the diagnosis and treatment or prevention of diseases caused by abnormal insertion or activity of a cell surface membrane protein, such as cystic fibrosis.

L'invention concerne des méthodes de criblage de composés régulant l'activité de protéines de surface. Elle concerne également une méthode qui permet de réguler l'insertion ou la rétention d'une protéine, telle que le régulateur de la perméabilité transmembranaire de la fibrose kystique (CFTR), dans une membrane de surface. L'invention concerne en outre des méthodes de diagnostic et de traitement ou de prévention de maladies causées par une insertion ou une activité anormale d'une protéine membranaire de surface, telle que la fibrose kystique.

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