C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2143453
A method for decreasing metalloproteinase activity in a patient that comprises the step of administering to said patient a therapeutic composition comprising the cytokine oncostatin-M, or a biologically active fragment, mutant, analog or fusion con- struct thereof. Also, a method for increasing TIMP activity in a patient that comprises the step of administering to said patient a therapeutic composition comprising the cytokine oncostatin-M, or a biologically active fragment, mutant, analog or fusion con- struct thereof. In addition a method for inhibiting or treating progression of a tumor in a patient that comprises the step of ad- ministering to said patient a therapeutic composition comprising oncostatin-M, or a biologically active fragment, mutant, analog, or fusion construct thereof, said method being effective to inhibit invasion by a tumor cell through an extracellular space, extrac- ellular matrix, basement membrane, interstitial tissue or connective tissue. Also methods effective to treat inflammatory or degen- erative disease, methods effective to stimulate erythropoiesis, and methods effective to regulate tissue remodeling and to promote healing of injury.
Brown Thomas Joseph
Gauldie Jack
Richards Carl D.
Shoyab Mohammed
Bristol-Myers Squibb Company
Mcmaster University
Smart & Biggar
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