Regulation of cytokine synthesis and release

A - Human Necessities – 61 – K

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A61K 38/57 (2006.01)

Patent

CA 2221601

Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.

L'invention concerne des procédés de traitement et de prévention des maladies associées à la libération de la neutrophile-élastase et de l'IL-8 par l'administration de l'inhibiteur de la voie du facteur tissulaire (TFPI) et d'analogues de celui-ci. Elle concerne également des procédés pour déterminer l'efficacité du traitement avec le TFPI, la réactivité du patient à un tel traitment et la détermination ultime du pronostic relatif au patient.

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