Regulation of estrus and ovulation in gilts

A - Human Necessities – 61 – K

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A61K 31/565 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 38/09 (2006.01) A61K 38/24 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2321102

Controlled release compositions and methods for inducing pseudopregnancy in gilts and sows are disclosed. In the preferred embodiment, the formulation includes polylactide microspheres releasing estradiol 17.beta. at physiologically useful levels over a period of time between five and thirty days. Following induction of pseudopregnancy, the pseudopregnancy can be terminated and estrus induced by administration of a compound such as PGF2.alpha.. The advantages of inducing pseudopregnancy followed by induction of estrus are that the breeding patterns of large numbers of gilts and sows can be controlled.

On décrit des compositions de libération et des procédés pouvant induire une pseudo-gestation chez des jeunes truies et des coches. Dans une forme de réalisation préférée, lesdites préparations incluent des microsphères polylactides libérant l'oestradiol 17.beta. à des doses physiologiquement appropriées pendant une durée comprise entre cinq et trente jours. Après induction d'une pseudo-gestation, la pseudo-gestation peut être terminée et suivie de l'induction de l'oestrus par administration d'un composé, tel que la prostaglandine PGF2.alpha.. L'induction de la pseudo-gestation puis de l'oestrus présente l'avantage de permettre de contrôler les modes de reproduction d'un grand nombre de jeunes truies et de coches.

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