Regulation of gene expression using single-chain, monomeric,...

Details Regulation of gene expression using single-chain, monomeric,... Regulation of gene expression using single-chain, monomeric,...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/72 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2415726

Single chain, monomeric polypeptide gene switches are provided. The gene switches include ligand binding domains and at least one functional domain. Preferred functional domains are DNA binding domains and transcriptional regulating domains. Methods of regulating gene function using the switches are also provided.

L'invention concerne des commutateurs de gènes polypeptidiques monomères à chaîne unique. Ces commutateurs de gènes comprennent des domaines de liaison de ligand et au moins un domaine fonctionnel. Les domaines fonctionnels préférés sont les domaines de liaison d'ADN et les domaines de régulation transcriptionnelle. L'invention concerne également des méthodes de régulation de fonction génique utilisant lesdites commutateurs.

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