Regulation of hematopoietic stem cell differentiation by the...

Details Regulation of hematopoietic stem cell differentiation by the... Regulation of hematopoietic stem cell differentiation by the...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/077 (2010.01) C12N 5/0797 (2010.01) A61K 35/12 (2006.01) A61K 35/32 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2680649

The invention relates to the induction of hematopoietic stem cells to differentiate into osteoclasts by culturing hematopoietic stem cells with human mesenchymal stem cells, and, in a preferred embodiment, using no exogenous cytokines. Differentiation of the mesenchymal stem cells into osteoblasts inhibited the differentiation of hematopoietic stem cells into osteoclasts. In addition, hematopoietic stem cells can be genetically engineered to carry genes of interest particularly for the expression of physiologically active proteins. In the presence of mesenchymal stem cells, the transduced cells carry the new

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