Regulation of her2/neu oncogene expression by synthetic...

Details Regulation of her2/neu oncogene expression by synthetic... Regulation of her2/neu oncogene expression by synthetic...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/00 (2006.01) A61K 31/4178 (2006.01)

Patent

CA 2344654

Methods and compositions comprising polyamides capable of binding the minor groove of double-stranded DNA are described for the inhibition or reduction of gene transcription and expression. The polyamides comprise at least four complementary pairs of aromatic carboxamide residues which are selected to specifically contact and/or bind to the nucleotide sequence of a double- stranded DNA target in the promoter region of the target gene. The methods, compositions and polyamides are disclosed for the inhibition of oncogene transcription and expression as well as the treatment of cancer.

L'invention concerne des procédés et des compositions comprenant des polyamides capables de se lier au sillon mineur d'un ADN à double brins, afin d'inhiber ou de réduire l'expression et la transcription géniques. Les polyamides comprennent au moins quatre paires complémentaires de restes de carboxamide aromatiques, sélectionnés afin de créer un contact et/ou se lier, de manière spécifique, avec la séquence de nucléotide d'une cible d'ADN à double brins dans la région de promoteur du gène cible. L'invention concerne également des procédés, des compositions et des polyamides qui permettent d'inhiber l'expression et la transcription oncogènes et de traiter le cancer.

Affiliated with

Also associated with

Rating

Regulation of her2/neu oncogene expression by synthetic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Regulation of her2/neu oncogene expression by synthetic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Regulation of her2/neu oncogene expression by synthetic... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1902112