G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2344971
Endophilin I is a brain-specific protein functioning in clathrin-mediated endocytosis. The present invention is based on the finding that the rat germinal center kinase-like kinase (rGLK), a member of the germinal center kinase (GCK) family of c-jun N-terminal kinase (JNK) activating enzymes, is a novel endophilin I-binding partner. In a first aspect of the present invention, the novel interaction between endophilin I and rGLK is put to use in a novel screening assay. In a second aspect of the present invention, the interaction between endophilin I and GLK is modulated for therapeutic purposes, namely for the prevention and/or curtailment of neurological disorders associated with the JNK pathway. JNK-mediated neuronal cell death is believed to play an important role in injuries and diseases involving neuronal degeneration, such as Huntington's disease.
Mcpherson Peter S.
Ramjaun Antoine Rachid
Goudreau Gage Dubuc
University Mcgill
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