Regulation of matrix metalloproteinases by psp94 family members

Details Regulation of matrix metalloproteinases by psp94 family members Regulation of matrix metalloproteinases by psp94 family members

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/17 (2006.01) A61K 38/57 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2545639

Matrix metalloproteinases (MMPs) play an important role in morphogenesis, angiogenesis, wound healing, and in certain disorders such as rheumatoid arthritis, tumor invasion and metastasis. MMPs are thought to be regulated by a variety of cytokines, growth factors, hormones and phorbol esters. This regulation occurs on three levels; alteration of gene expression, activation of the latent zymogen and inhibition by the tissue inhibitors of metalloproteinases (TIMP). We report here a new agent that regulates the level of MMPs in patient. More particularly, members of the PSP94 family, when administered to patients having metastatic hormone resistant prostate cancer, promote a significant decrease in MMP plasma levels. The invention therefore relates to the use of a PSP94 family member for the treatment of a condition related to the activity or expression of MMPs.

Les métalloprotéinases matricielles (MMP) jouent un rôle important dans la morphogenèse, l'angiogenèse, la cicatrisation des blessures et dans certains troubles, notamment dans la polyarthrite rhumatoïde, l'invasion tumorale et la métastase. On suppose que les MMP sont régulées par une grande variété de cytokines, de facteurs de croissance, d'hormones et d'esters phorbol. Cette régulation apparaît sur trois niveaux: l'altération de l'expression génique, l'activation du zymogène latent et l'inhibition par les inhibiteurs tissulaires de métalloprotéinases (TIMP). Nous avons découvert un nouvel agent régulant le niveau de MMP chez les patients. De manière plus spécifique, les éléments de la famille PSP94, une fois administrés à des patients ayant un cancer de la prostate hormono-résistant métastasique, favorisent une diminution considérable des niveaux de plasma MMP. L'invention porte par conséquent sur l'utilisation d'un élément de la famille PSP94 pour le traitement d'une pathologie liée à l'activité ou à l'expression de MMP.

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