Regulation of matrix metalloproteinases by psp94 family members

Details Regulation of matrix metalloproteinases by psp94 family members Regulation of matrix metalloproteinases by psp94 family members

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/17 (2006.01) A61K 38/57 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2441695

Matrix metalloproteinases (MMPs) play an important role in morphogenesis, angiogenesis, wound healing, and in certain disorders such as rheumatoid arthritis, tumor invasion and metastasis. MMPs are thought to be regulated by a variety of cytokines, growth factors, hormones and phorbol esters. This regulation occurs on three levels; alteration of gene expression, activation of the latent zymogen and inhibition by the tissue inhibitors of metalloproteinases (TIMP). We report here a new agent that regulates the level of MMPs in patient. More particularly, members of the PSP94 family, when administered to patients having metastatic hormone resistant prostate cancer, promote a significant decrease in MMP plasma levels. The invention therefore relates to the use of a PSP94 family member for the treatment of a condition related to the activity or expression of MMPs.

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