Regulation of muscle tissues by hedgehog-like polypeptides,...

Details Regulation of muscle tissues by hedgehog-like polypeptides,... Regulation of muscle tissues by hedgehog-like polypeptides,...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/00 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/55 (2006.01) A61K 31/553 (2006.01) A61K 31/70 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2302780

The present application relates to a method for modulating the formation and/or maintenance of muscle tissue by ectopically contacting muscle cells, especially muscle stem/progenitor cells, in vitro or in vivo, with a hedgehog therapeutic or ptc therapeutic in an amount effective to alter the growth state the treated cells, e.g., relative to the absence of administration of the hedgehog therapeutic or ptc therapeutic.

L'invention concerne un procédé servant à moduler la formation et/ou l'entretien de tissus musculaires, par la mise en contact ectopique de cellules musculaires, en particulier de cellules souches/ précurseurs de muscle, in vitro ou in vivo, avec un traitement "hedgehog" ou un traitement "ptc" en quantité efficace pour modifier l'état de croissance des cellules traitées, p. ex. par rapport à l'absence d'administration de traitement "hedgehog" ou de traitement "ptc".

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