Regulation of organic nitrate tolerance

Details Regulation of organic nitrate tolerance Regulation of organic nitrate tolerance

A - Human Necessities

61

K

A61K 31/04 (2006.01) A61K 31/34 (2006.01) A61K 31/495 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2434072

There is disclosed pharmaceutical compositions and methods useful in obviating or mitigating tolerance during organic nitrate therapy. The compositions and methods comprise compounds selected from the group comprising a folate compound, a folate derivative compound, a hydrobiopterin compound, a hydrobiopterin derivative compound and mixtures thereof.

Cette invention se rapporte à des compositions pharmaceutiques et à des procédés servant à éliminer et à atténuer la tolérance lors d'une thérapie à base de nitrates organiques. Ces compositions et ces procédés utilisent des composés choisis dans le groupe constitué par un composé de folate, un composé de dérivé de folate, un composé d'hydrobioptérine, un composé de dérivé d'hydrobioptérine et des mélanges de ceux-ci.

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