Regulation of protein synthesis by inhibition of eif4e-eif4g...

A - Human Necessities – 61 – K

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A61K 31/426 (2006.01) A61K 31/515 (2006.01) A61P 35/00 (2006.01) C07D 277/20 (2006.01) C07D 277/28 (2006.01) C07D 277/42 (2006.01) C07D 277/46 (2006.01) C07D 277/50 (2006.01) C07D 277/56 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2619153

A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.

L'invention porte sur une composition et sur un procédé qui permettent d'inhiber la prolifération d'une cellule tumorale par comparaison avec une cellule non tumorale. L'invention concerne également des procédés de criblage d'une composition qui inhibe la traduction dépendante de la coiffe par comparaison avec la traduction indépendante de la coiffe des protéines.

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