Regulation of t-cell proliferation via a novel 5htla receptor

Details Regulation of t-cell proliferation via a novel 5htla receptor Regulation of t-cell proliferation via a novel 5htla receptor

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 31/135 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2090689

ABSTRACT A method of regulating proliferation of activated T cells exhibiting a 5HT1a receptor by introducing a sufficient amount of agonists or antagonists to either increase or decrease T cell proliferation. The basis for regulating cell proliferation may be (1) via the 5HT receptor, (2) via serotonin synthesis inhibition and/or (3) via serotonin stimulation of CD8+ subpopulations of activated T cells.

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