Regulation of tool-like receptors on stem cells

Details Regulation of tool-like receptors on stem cells Regulation of tool-like receptors on stem cells

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2624087

The discovery of Toll-like receptors (TLRs) on the surface of hematopoietic cells provides new methods for the stimulation and differentiation of various classes of progenitor cells. TLR2 and TLR4 agonists (natural ligands, mimetics, antibodies) are particularly useful in these methods. The cells can be isolated and used for various purpose including tissue regeneration and grafting, hi contrast, antagonists of TLRs can be used to protect cells from various insults such as chemo- and radiotherapy, acute and chronic infection, and transplantation by inhibiting activation and differentiation. TLR2, TLR4 and TLR9 pathway antagonists (soluble TLR, mimetics, antibodies) are particularly useful in these methods. Cells can be isolated and used for various purposes including transplantation.

La découvert de récepteurs du type Toll (TLR) sur la surface des cellules hématopoïétiques donne lieu à de nouvelles méthodes pour la stimulation et la différenciation de diverses classes de cellules progénitrices. Les agonistes de TLR2 et de TLR4 (ligands naturels, mimétiques, anticorps) sont particulièrement utiles dans ces méthodes. Ces cellules peuvent être isolées et utilisées pour diverses finalités notamment la régénération et le greffage tissulaire. Les antagonistes de la voie TLR peuvent servir à protéger des cellules contre différentes attaques, notamment chimiothérapiques et radiothérapiques, l'infection aiguë et chronique et la transplantation en inhibant l'activation et la différenciation. Les antagonistes des voies TLR2, TLR4 et TLR9 (TLR soluble, mimétiques, anticorps) sont particulièrement utiles dans ces méthodes. Des cellules peuvent être isolées et utilisées pour diverses finalités notamment la transplantation.

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