Regulation of transcription factor, nf-il6/lap

Details Regulation of transcription factor, nf-il6/lap Regulation of transcription factor, nf-il6/lap

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2167303

.delta. An alteration in phosphorylation of serine 105, within the activation domain of NF-IL6/LAP, alters its transcription efficacy. Polypeptides, polynucleotides and methods of use for modified transcriptional activators allow regulation of gene expression. The figure shows CAT activity for HepG2 cells co-transfected with a CAT reporter plasmid and pCMV-LAP(wt), pCMV-LAP(Ala105), and pCMV- LAP(Asp) plasmids.

En modifiant la phosphorylation de la sérine 105 à l'intérieur du domaine d'activation du NF-IL6/LAP, on en altère l'efficacité de transcription. Des polypeptides, des polynucléotides et leur méthode d'utilisation comme activateurs de transcription modifiés permettent de réguler l'expression de gènes. La figure illustre l'activité CAT de cellules HepG2 cotransfectées à l'aide d'un plasmide reporteur CAT et de plasmides pCMV-LAP(wt), pCMV-LAP(Ala105) et pCMV-LAP(Asp).

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