Regulation system of expression using nuclear ppar receptors

Details Regulation system of expression using nuclear ppar receptors Regulation system of expression using nuclear ppar receptors

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2375869

The invention concerns novel methods and compositions for the pharmacological regulation of the expression of transgenes. More particularly, it concerns a composition comprising: (a) a first element comprising a nucleic acid of interest under the control of an inducible promoter comprising an element containing a response element to a PPAR and a minimal transcriptional receptor; and (b) a second element comprising a nucleic acid coding for a PPAR under the control of a transcriptional promoter, for simultaneous, separate or prolonged use. The invention concerns the use of said compositions and methods in the experimental, clinical, therapeutic or diagnostic fields.

La présente invention concerne de nouvelles méthodes et compositions pour la régulation pharmacologique de l'expression de transgènes. Elle concerne plus particulièrement une composition comprenant: (a) un premier élément comprenant un acide nucléique d'intérêt sous contrôle d'un promoteur inductible comprenant un élément de réponse à un PPAR et un promoteur transcriptionnel minimal, et (b) un deuxième élément comprenant un acide nucléique codant un PPAR sous contrôle d'un promoteur transcriptionnel, en vue de leur utilisation simultanée, séparée ou espacée dans le temps. L'invention concerne l'utilisation de ces compositions et méthodes dans les domaines expérimentaux, cliniques, thérapeutiques ou diagnostiques.

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