Regulators of the hedgehog pathway, compositions and uses...

Details Regulators of the hedgehog pathway, compositions and uses... Regulators of the hedgehog pathway, compositions and uses...

C - Chemistry, Metallurgy

07

J

C07J 69/00 (2006.01) A61K 31/58 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2386190

The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.

La présente invention concerne, entre autres, des méthodes et des réactifs pouvant moduler l'activité du signal Smoothened. Dans certaines formes de réalisation, lesdites méthodes peuvent être utilisées pour contrecarrer les effets phénotypiques d'une activité non désirée d'un signal Hedgehog, telle que résultant de mutations par gain-de-fonction Hedgehog, par perte-de-fonction ptc, ou par gain-de-fonction Smoothened.

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