C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2407737
The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. The invention also relates to nucleotide constructs comprising a polynucleotide which encodes a polypeptide or a nucleic acid of interest, placed under the control a regulatory nucleic acid for the ABC1 gene. The invention also relates to recombinant vectors, transformed host cells and nonhuman transgenic mammals comprising a nucleic acid which regulates the transcription of the ABC1 gene or an abovementioned nucleotide construct, as well as methods for screening molecules or substances which are capable of modifying the activity of the regulatory nucleic acid for the ABC1 gene.
La présente invention concerne un acide nucléique capable de réguler la transcription du gène ABC1, qui est le gène provoquant des pathologies liées su dysfonctionnement du métabolisme du cholestérol, induisant des maladies telles que l'athérosclérose. L'invention concerne également des constructions nucléotidiques comportant un polynucléotide codant pour un polypeptide ou un acide nucléique d'intérêt, placé sous le contrôle d'un acide nucléique régulateur du gène ABC1. L'invention concerne en outre des vecteurs recombinants, des cellules transformées et des mammifères transgéniques non humains comportant un acide nucléique régulateur de la transcription du gène ABC1 ou d'une construction nucléotidique susmentionnée, ainsi que des procédés de criblage de molécules ou de substances capables de modifier l'activité de l'acide nucléique régulateur du gène ABC1.
Brewer Bryan
Denefle Patrice
Duverger Nicolas
Lemoine Cendrine
Naudin Laurent
Aventis Pharma S.a.
Robic
LandOfFree
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