Rehydratable polysaccharide particles and sponge

Details Rehydratable polysaccharide particles and sponge Rehydratable polysaccharide particles and sponge

C - Chemistry, Metallurgy

08

L

C08L 1/28 (2006.01) A61K 9/00 (2006.01) A61K 31/045 (2006.01) A61L 15/22 (2006.01) A61L 15/28 (2006.01) A61L 15/42 (2006.01) A61L 15/60 (2006.01) A61L 31/04 (2006.01) A61L 31/14 (2006.01) C08B 15/00 (2006.01) C08J 3/075 (2006.01) C08L 5/08 (2006.01)

Patent

CA 2721986

Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.

Le tissu et les autres structures anatomiques peuvent être protégés au moyen d'une composition hydratée faite de particules libres réhydratables de polysaccharide sensiblement exempt de collagène et d'éponges de polysaccharide. La réhydratation non agglutinante des particules peut se faire en dispersant les particules dans un dispersant polaire biocompatible miscible à l'eau tel que l'éthanol, et en combinant la dispersion à une quantité suffisante de solvant aqueux permettant aux particules de se convertir en un hydrogel cohésif. Cette composition hydratée peut aider à rétablir à un état normal une surface lésée, enflammée, ou chirurgicalement réparée, par exemple au moyen d'un ou de plusieurs mécanismes de guérison tels que la modulation d'une réponse inflammatoire, la phagocytose, le remodelage muqueux, la reciliation ou tout autre rétablissement total ou partiel de fonction normale.

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