Rehydratable thiolated polysaccharide particles and sponge

Details Rehydratable thiolated polysaccharide particles and sponge Rehydratable thiolated polysaccharide particles and sponge

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) A61L 15/22 (2006.01) A61L 15/28 (2006.01) A61L 15/42 (2006.01) A61L 15/60 (2006.01) A61L 31/04 (2006.01) A61L 31/14 (2006.01) C08B 37/00 (2006.01) C08L 5/08 (2006.01)

Patent

CA 2722145

Tissue and other body structures may be protected using a hydrated composition made from free-flowing rehydratable particles or a rehydratable sponge comprising substantially collagen-free dehydrothermally crosslinked thiolated polysaccharide. Rehydration of crosslinked or uncrosslinked polysaccharide particles may be carried out without clumping by dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated particles or sponge may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.

Du tissu et d'autres structures anatomiques peuvent être protégés au moyen d'une composition hydratée faite de particules libres réhydratables ou d'une éponge réhydratable comportant du polysaccharide thiolé réticulé par déshydratation thermique, sensiblement exempt de collagène. La réhydratation des particules de polysaccharide réticulé ou non-réticulé peut se faire sans agglutination en dispersant les particules dans un dispersant polaire biocompatible miscible à l'eau tel que l'éthanol, et en combinant la dispersion à une quantité suffisante de solvant aqueux permettant aux particules de se convertir en un hydrogel cohésif. Cette éponge ou ces particules hydratées peuvent aider à rétablir à un état normal une surface lésée, enflammée, ou chirurgicalement réparée, par exemple au moyen d'un ou de plusieurs mécanismes de guérison tels que la modulation d'une réponse inflammatoire, la phagocytose, le remodelage muqueux, la reciliation ou tout autre rétablissement total ou partiel de fonction normale.

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