A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) B01J 13/18 (2006.01)
Patent
CA 2062726
ABSTRACT OF THE DISCLOSURE Disclosed are paucilamellar lipid vesicles reinforced with polyacrylamide, and methods of producing the same. The vesicles include about 2-10 lipid bilayers in the form of substantially spherical shells separated by a plurality of aqueous layers. Each of the bilayers have a layer of polyacrylamide lining its innermost side. The bilayers and the aqueous layers surround a large, substantially amorphous central cavity containing a water- immiscible oily phase or a polyacrylamide core. The method of the invention includes forming a lipophilic phase containing a surfactant and a lipid-soluble material to be encapsulated or to be incorporated into the lipid structure of the vesicle; forming an aqueous phase containing polyacrylamide; shear mixing the lipophilic phase and the aqueous phase, therby forming a plurality of paucilamellar lipid vesicles containing acrylamide in their aqueous regions; separating the vesicles from any unincorporated vesicle constituents; and polymerizing the acrylamide in the aqueous layers of the vesicles. A method of encapsulating a water-soluble material is also disclosed.
Micro-Pak Inc.
Riches Mckenzie & Herbert Llp
LandOfFree
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