Relaxin levels correlated to ivf/et pregnancy success

G - Physics – 01 – N

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G01N 33/74 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2294177

A method of determining the probability of an <u>in vitro</u> fertilization (IVF) or embryo transfer (ET) method being successful is disclosed. Relaxin can be measured directly in the serum or indirectly by culturing granulosa lutein cells extracted from the patient as part of an IVF/ET procedure. A method of enhancing the rate of a successful pregnancy resulting from an IVF/ET procedure is also disclosed whereby relaxin is administered and/or endogenous relaxin levels are enhanced by varying convention IVF/ET procedures.

Cette invention se rapporte à un procédé permettant d'évaluer la probabilité de succès d'un procédé de fécondation <u>in vitro</u> (FIV) ou de transplantation d'embryon (TE). Pour ce faire, on mesure directement le taux de relaxine dans le sérum ou indirectement en procédant à la culture de cellules lutéiniques folliculaires prélevées chez une patiente lors de la procédure de FIV/TE. Cette invention se rapporte à un procédé permettant d'accroître le taux de succès de conception par fécondation in vitro ou transplantation d'embryon, ledit procédé consistant à administrer de la relaxine et/ou à accroître les taux de relaxine endogène en modifiant les procédures conventionnelles de VIF/TE.

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