C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) A61K 47/28 (2006.01) C07J 51/00 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2742776
The present invention is directed to releasable cationic lipids and nanoparticle compositions for the delivery of nucleic acids and methods of modulating an expression of a target gene using the same. In particular, the invention relates to cationic lipids including an acid labile linker, and nanoparticle compositions containing the same.
La présente invention concerne, d'une part des lipides cationiques libérables et des compositions de nanoparticules pour l'administration d'acides nucléiques, et d'autre part des procédés permettant de moduler une expression de gène cible au moyen de ces lipides et compositions. L'invention concerne plus particulièrement des lipides cationiques comportant un lieur acide labile, et des compositions de nanoparticules les contenant.
Royzen Maksim
Shi Lianjun
Wu Dechun
Yan Weili
Zhao Hong
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Enzon Pharmaceuticals Inc.
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