C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A01N 43/04 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 5/00 (2006.01) C07K 7/02 (2006.01) C07K 7/06 (2006.01) C12N 15/87 (2006.01) A61K 31/7088 (2006.01)
Patent
CA 2742842
The present invention is directed to nucleic acids delivery systems and methods of modulating an expression of a target gene using the same. In particular, the invention relates to nucleic acids conjugates containing an endosomal release-promoting moiety. The nucleic acids conjugates further contain a nuclear localization signal moiety, and/or a cell targeting moiety.
La présente invention concerne des systèmes d'administration d'acides nucléiques et des procédés permettant de moduler l'expression, par ces systèmes, d'un gène cible. L'invention concerne plus particulièrement des conjugués contenant un groupe fonctionnel promouvant la libération endosomale. Ces conjugués d'acides nucléiques contiennent en outre un groupe fonctionnel à signal de localisation nucléaire, et/ou un groupe fonctionnel ciblant les cellules.
Reddy Prasanna
Xia Jing
Zhao Hong
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Enzon Pharmaceuticals Inc.
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