C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/24 (2006.01) A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 47/28 (2006.01) C07C 251/18 (2006.01) C07F 9/10 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2742846
The present invention relates to releasable fusogenic lipids and nanoparticle compositions containing the same for the delivery of oligonucleotides and methods of modulating gene expression using the same. In particular, this invention relates to releasable fusogenic lipids containing an imine linker and a zwitterionic moiety.
La présente invention concerne des lipides fusogènes libérables et des compositions nanoparticulaires contenant ces lipides pour la délivrance d'oligonucléotides, ainsi que des procédés de modulation de l'expression génique basés sur ces lipides. En particulier, cette invention concerne des lipides fusogènes libérables contenant un lieur à base dimine et une fraction amphotère.
Royzen Maksim
Shi Lianjun
Wu Dechun
Yan Weili
Zhao Hong
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Enzon Pharmaceuticals Inc.
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