A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2547255
A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.
Cette invention concerne un conjugué comprenant un polymère hydrophile lié de manière covalente mais réversible à un ligand contenant une amine, un hydroxy ou un carboxyle. Le conjugué ainsi obtenu est capable de libérer le composé parent contenant une amine, un hydroxy ou un carboxyle par le biais d'un clivage induit par un thiol. Le système de cette invention permet d'administrer divers médicaments contenant une amine, un hydroxy ou un carboxy sous la forme de leurs conjugués macromoléculaires thiolytiquement clivables.
Kiwan Radwan
Zalipsky Samuel
Alza Corporation
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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