A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/104, 195/34.
A61K 35/28 (2006.01) C12Q 1/24 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2014965
The present invention discloses a method for releasing animal cells bound to antibodies specific for the MY10 epitope which comprises treating the antibody bound animal cells with chymopapain and separating the viable cells from said antibodies. The invention also provides a method for the purification of lymphohematopoietic precursor cells from a population of human CD34-positive cells. Both of these methods are important for the positive selection of normal marrow stem cells for treatment of bone marrow grafts required for bone marrow transplantation in diseases such as aplastic anemia and leukaemia.
La méthode faisant l'objet de la présente divulgation consiste à libérer des cellules animales liées à des anticorps spécifiques de l'épitope MY10 par traitement à la chymopapaïne des cellules animales liées à l'anticorps et séparation des cellules viables de ces anticorps. Le brevet porte aussi sur une méthode de purification des cellules précurseurs lymphohématopoïétiques d'une population de cellules humaines positives CD34. Ces deux méthodes sont importantes en vue de la sélection positive de cellules souches de moelle normales pour le traitement des greffes de moelle osseuse nécessaires pour la transplantation de moelle dans les cas de maladies comme l'anémie aplasique et de leucémie.
Johns Hopkins University
Sim & Mcburney
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