Release of lipophilic active agents from chewing gum

Details Release of lipophilic active agents from chewing gum Release of lipophilic active agents from chewing gum

A - Human Necessities

23

G

A23G 4/08 (2006.01) A23G 4/00 (2006.01) A61K 9/68 (2006.01)

Patent

CA 2394290

A method for producing a chewing gum with an improved release of a lipophilic acive agent, as well as the chewing gum so produced, is obtained by using a hydrophilic gum base. The preferred and novel gum base includes hydrophilic polymers, hydrophilic softeners/emulsifiers and fillers, but is essentially free of hydrophobic elastomers and hydrophobic softeners, as well as waxes and elastomer solvents. The lipophilic active agent is preferably added to a coating on a chewing gum pellet made using a hydrophilic gum base, such as by being mixed into a coating solution. The coating solution may contain a high-intensity sweetener. An active agent may also be used in the gum core.

Selon l'invention, un procédé de production de chewing gum à libération améliorée d'un principe actif lipophile, ainsi que le chewing gum ainsi produit, est obtenu par utilisation d'une base de chewing-gum hydrophile. Une base de chewing gum préférée comprend des polymères hydrophile, des ramollissants/ émulsifiants hydrophiles et des agents de charge, mais est essentiellement exempte d'élastomères hydrophobes et de ramollissants hydrophobes, ainsi que de cires et de solvants élastomères. Le principe actif lipophile est, de préférence, ajouté à un enrobage sur une dragée de chewing gum fabriquée avec une base de chewing-gum hydrophile, telle que par mélange dans une solution d'enrobage. La solution d'enrobage peut contenir un édulcorant à très haute densité. Un principe actif lipophile peut également être utilisé dans la partie centrale du chewing-gum.

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