Release of poorly soluble agents

Details Release of poorly soluble agents Release of poorly soluble agents

A - Human Necessities

61

K

A61K 9/50 (2006.01)

Patent

CA 2374051

A controlled release pellet for releasing a poorly soluble active agent comprises a core containing the active agent (e.g. nifedipine, glibenclamide, griseofulvin, oxaprozin, ibuprofen, diclofenac, nabumetone etc.), a polyethylene glycol and a carrier; the core having a coating comprising a water soluble cellulose and a water insoluble acrylic polymer. A disintegrating agent is preferably included in the core.

La présente invention concerne une pastille à libération contrôlée destinée à libérer un principe actif faiblement soluble présentant un noyau qui contient le principe actif (comme par exemple, la nifédipine, le glibenclamide, la griséofulvine, l'oxaprozine, l'ibuprofène, le diclofénac, la nabumétone etc.), un glycol polyéthylène et un excipient; le noyau présentant un enrobage à base de cellulose hydrosoluble et de polymère acrylique non hydrosoluble. En outre, un agent de désintégration est de préférence contenu dans le noyau.

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