Remedies for amyotrophic lateral sclerosis

Details Remedies for amyotrophic lateral sclerosis Remedies for amyotrophic lateral sclerosis

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 31/711 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2422774

Remedies (progression inhibitors) for amyotrophic lateral sclerosis (ALS) which contain as the active ingredient HGF and/or HGF gene. HGF has two functions, i.e., a direct neurotrophic factor activity on motoneurons and an indirect effect of relieving glutamic acid cytotoxicity on motoneurons by maintaining the glutamic acid transporter level in astrocytes, thereby improving the motor function and prolonging the life of patients with ALS. Thus, HGF and/or HGF gene can be effectively used as efficacious remedies that have never been known hitherto.

L'invention concerne des remèdes (inhibiteurs de progression) contre la sclérose latérale amyothrophique (SLA) contenant en tant que principe actif HGF et/ou un gène HGF. Le HGF (facteur de croissance des hétapocytes) présente deux fonctions, c'est-à-dire, une activité de facteur neurotrophique directe sur les motoneurones et un effet indirect de soulagement de la cytotoxicité de l'acide glutamique sur les motoneurones par maintien du niveau de transporteur d'acide glutamique dans les astrocytes, améliorant ainsi la fonction motrice et prolongeant la durée de vie de patients atteints de SLA. Ainsi, le HGF et/ou le gène du HGF peuvent être utilisés efficacement en tant que remèdes efficaces inconnus jusqu'à présent.

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