Remedies for pemphigus containing anti fas ligand antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 17/00 (2006.01) A61P 37/06 (2006.01) C12N 5/12 (2006.01)

Patent

CA 2708790

Disclosure of the use of FasL antagonists, e.g. of humanized antibodies directed against human Fas ligands (also named CD95L or Apo1L and hereinafter abbreviated as FasL) for the prevention and/or treatment of skin diseases associated with keratinocytes acantholysis, particularly for the prevention and/or treatment of pemphigus.

La présente invention porte sur l'utilisation d'antagonistes de FasL, par exemple, d'anticorps humanisés dirigés contre des ligands Fas humains (également appelés CD95L ou Apo1 L, et désignés ci-après par l'abréviation FasL) pour la prévention et/ou le traitement de maladies de peau associées à l'acantholyse de kératinocytes, en particulier pour la prévention et/ou le traitement du pemphigus.

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