Remedies/preventives for frequent urination/urinary...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/14 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 213/74 (2006.01) C07D 241/04 (2006.01) C07D 295/10 (2006.01) C07D 295/116 (2006.01) C07D 295/135 (2006.01)

Patent

CA 2294312

Remedies/preventives for frequent urination/urinary incontinence which contain as the active ingredient compounds having a tropone skeleton or pharmacologically acceptable salts thereof; and novel compounds having the tropone skeleton. The compounds having a tropone skeleton and showing the above pharmacological effects are those represented by, for example, general formula (1), wherein R1 and R2 represent each hydrogen, lower alkyl, etc.; R3 represents -OR or -NR2; R4, R5 and R12 represent each hydrogen or lower alkyl; X represents nitrogen or CH; Z represents -CHAr2, optionally substituted phenyl, etc.; and m is 1 or 2. These compounds are novel ones excluding those wherein Z is -CHAr2.

L'invention concerne des médicaments pour le traitement/la prévention des mictions fréquentes et de l'incontinence urinaire, contenant en tant que principe actif des composés possédant un squelette tropone ou des sels de ces composés, acceptables sur le plan pharmacologique. L'invention concerne également des nouveaux composés, lesquels possèdent le squelette tropone, démontrent les effets pharmacologiques ci-dessus et sont représentés, par exemple, par la formule générale (1), dans laquelle R?1¿ et R?2¿ représentent chacun hydrogène, alkyle inférieur, etc.; R?3¿ représente -OR ou -NR¿2?, R?4¿, R?5¿ et R?12¿ représentent chacun hydrogène ou alkyle inférieur, X représente azote ou CH, Z représente -CHAr¿2?, phényle éventuellement substitué, etc.;, et m vaut 1 ou 2. Ces composés sont nouveaux à l'exception de ceux dans la formule desquels Z représente -CHAr¿2?.

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