Remedy for alzheimer's disease

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/22 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2588868

It is intended to provide a preventive/remedy for Alzheimer~s disease which contains, as the active ingredient(s), a substance inhibiting the suppressive effect of .beta.-amyloid 1-40 on the differentiation of vascular endothelial cell precursors and/or the suppressive effect of thereof on the differentiation of stem cells into endothelium precursor and/or a substance promoting angiogenesis. It is also intended to provide a method of screening a substance inhibiting the suppressive effect of .beta.-amyloid 1-40 on the differentiation of vascular endothelial cell precursors and/or the suppressive effect of thereof on the differentiation of stem cells into endothelium precursor and/or a substance promoting angiogenesis.

La présente invention a pour objet un médicament prophylactique/thérapeutique contre la maladie d'Alzheimer qui contient, au titre de principe(s) actif(s), une substance inhibant l'effet suppresseur du .beta.-amyloïde 1-40 sur la différentiation des cellules précurseurs vasculaires endothéliales et/ou l~effet suppresseur dudit amyloïde sur la différentiation des cellules souches dans un précurseur de l~endothélium et/ou une substance favorisant l~angiogenèse. La présente invention a également pour objet une méthode de criblage d~une substance inhibant l'effet suppresseur du .beta.-amyloïde 1-40 sur la différentiation des cellules précurseurs vasculaires endothéliales et/ou l~effet suppresseur dudit amyloïde sur la différentiation des cellules souches dans un précurseur de l~endothélium et/ou une substance favorisant l~angiogenèse.

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