A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 31/33 (2006.01) A61K 31/41 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 45/00 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2257284
A preventive or therapeutic agent for autoimmune diseases (excluding Type I diabetes) comprising a thiazolidinedione compound, preferably as defined in Formula (I): (see figure I) wherein: R1a and R2a may be the same or different and each represents a hydrogen atom or a C1-C5 alkyl group; R3a represents a hydrogen atom, a C1-C6 aliphatic acyl group, a C6-C8 cycloalkylcarbonyl group, a benzoyl or naphthoyl group which may have a substituent (the substituent is a C1-C4 alkyl, C1-C4 alkoxy or hydroxy group, a halogen atom, or an amino, mono-C1-C4 alkylamino, di-C1-C4 alkylamino or nitro group), a 4- to 7- membered heterocyclic acyl group containing from 1 to 3 hetero atoms selected from the hetero atom group consisting of nitrogen, oxygen and sulfur atoms, a phenylacetyl group, a phenylpropionyl group, a phenylacetyl or phenylpropionyl group substituted with at least one halogen atom, a cinnamoyl group, a C2-C7 alkoxycarbonyl group or a benzyloxycarbonyl group; R4a and R5a may be the same or different and each represents a hydrogen atom, a C1-C5 alkyl group or a C1-C5 alkoxy group, or R4' and R5' taken together represent a C1-C4 alkylenedioxy group; Y a and Z a each represents an oxygen atom; and n' is an integer of 1 to 3; or a pharmacologically acceptable salt thereof.
Cette invention se rapporte à un agent de prévention ou de traitement de maladies auto-immunes à l'exception du diabète de type I, ledit agent contenant en tant qu'ingrédient actif une substance améliorant la résistance insulinique.
Fujita Takashi
Fujiwara Toshihiko
Fukushige Junichiro
Horikoshi Hiroyoshi
Hosokawa Tsunemichi
Marks & Clerk
Sankyo Company Limited
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