C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/505 (2006.01)
Patent
CA 2151971
The present invention is to offer a rapid-acting remedy for asthma having a bronchodilating action. A remedy for bronchial asthma containing the pyrido[2,3-d]pyrimidine derivatives represented by the general formula (A) or pharmaceutically acceptable salts thereof as an effective component. Image (A) [In the formula, R1 and R2 are same or different and each of them is hydrogen, alkyl or benzyl; R3 is hydrogen, hydroxyl, dialkylaminomethyleneamino or -NH-X; X is hydrogen, alkyl, alkenyl, hydroxyl, amino, hydroxyalkyl, benzyl or acyl; R4 is hydrogen, alkyl, halogen, nitro, amino, hydroxyl, benzyloxy, cyano, carboxyl, alkoxycarbonyl, alkoxysulfonyl, aminosulfonyl, dialkylaminosulfonyl or sulfo; and R5 is hydrogen, alkyl or amino.] The rapid-acting remedy for bronchial asthma of the present invention which is capable of relieving the symptom of laboring breath at the onset of asthma due to its excellent bronchodilating action can be used as a therapy not only for allergic asthma but also for various bronchial asthma such as endogenous asthma, exogenous asthma and dust asthma.
Furukawa Kazuhito
Hasegawa Taisuke
Kirby Eades Gale Baker
Nippon Zoki Pharmaceutical Co. Ltd.
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