Removal of dye-labeled dideoxy terminators from dna...

Details Removal of dye-labeled dideoxy terminators from dna... Removal of dye-labeled dideoxy terminators from dna...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 51/00 (2006.01) A61M 36/14 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01) G01N 1/00 (2006.01)

Patent

CA 2386820

This invention provides methods for removing unincorporated dye-labeled molecules from a mixture that includes dye-labeled polynucleotides or other polymers and the unincorporated dye-labeled molecules. The methods involve adsorbing the unincorporated dye-labeled molecules into a plurality of particles that are made up of one or more porous hydrophobic materials that are encapsulated in a hydrophilic matrix.

L'invention concerne des procédés destinés à extraire des molécules non incorporées marquées par colorant, à partir d'un mélange contenant des polynucléotides marqués par colorant ou d'autres polymères, et les molécules non incorporées marquées par colorant. Ces procédés consistent à adsorber les molécules non incorporées marquées par colorant dans une pluralité de particules composées d'une ou plusieurs matières hydrophobes poreuses encapsulées dans une matrice hydrophile.

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