Removal of high molecular weight aggregates using...

Details Removal of high molecular weight aggregates using... Removal of high molecular weight aggregates using...

C - Chemistry, Metallurgy

07

K

C07K 16/06 (2006.01) B01D 15/08 (2006.01)

Patent

CA 2543193

This invention relates to the application of hydroxyapatite chromatography to the purification of at least one antibody from a preparation containing high molecular weight aggregates. Further, this invention relates to an integration of ceramic hydroxyapatite chromatography into a combination chromatographic protocol for the removal of high molecular weight aggregates from an antibody preparation.

La présente invention a trait à l'application de la chromatographie sur gel d'hydroxyapatite pour la purification d'au moins un anticorps dérivé d'une préparation contenant des agrégats à poids moléculaire élevé. L'invention a également trait à une intégration de la chromatographie sur céramique d'hydroxyapatite dans un protocole de combinaison chromatographique pour l'élimination d'agrégats à poids moléculaire élevé d'une préparation d'anticorps.

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