Removal of myoglobin from blood and/or physiological fluids

Details Removal of myoglobin from blood and/or physiological fluids Removal of myoglobin from blood and/or physiological fluids

A - Human Necessities

61

M

A61M 1/38 (2006.01) A61M 1/36 (2006.01) B01D 15/00 (2006.01) B01J 20/26 (2006.01) C08F 2/20 (2006.01) C08J 9/00 (2006.01)

Patent

CA 2729340

A polymer sorbent clears myoglobin from blood and/or other physiological fluids and solutions. Normal saline or human serum in which myoglobin was dissolved is perfused by a peristaltic pump through a column packed with the polymer sorbent. After a four-hour perfusion, the myoglobin level in normal saline fell from initial levels to virtually undetectable levels. Perfusion through the polymer sorbent was then found to lower concentrations of dissolved myoglobin to a significant degree in samples of human serum after four hours, indicating that the polymer sorbent is an effective sorbent for myoglobin.

L'invention fait appel à un sorbant polymère pour éliminer la myoglobine présente dans le sang et/ou d'autres liquides et solutions physiologiques. Selon l'invention, on introduit par perfusion à l'aide d'une pompe péristaltique dans une colonne remplie du sorbant polymère une solution saline ou un sérum humain normal dans lequel de la myoglobine a été dissoute. Après une perfusion de quatre heures, le niveau de myoglobine présent dans la solution saline normale chute de son niveau initial à des niveaux pratiquement indétectables. Il a été découvert que la perfusion à travers un sorbant polymère réduisait d'un degré significatif les concentrations de myoglobine dissoute dans des échantillons de sérum humain après quatre heures, ce qui indique que le sorbant polymère constitue un sorbant efficace pour la myoglobine.

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