Removing lps pyrogen from aqueous solution

Details Removing lps pyrogen from aqueous solution Removing lps pyrogen from aqueous solution

A - Human Necessities

61

K

167/100, 182/11,

A61K 39/00 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) B01D 15/00 (2006.01) B01D 39/08 (2006.01)

Patent

CA 2037727

ABSTRACT OF THE DISCLOSURE A method for removing LPS pyrogens from aqueous solutions is provided herein. The method comprises passing such aqueous solution through a filter comprising a macroporous hydrophobic cloth which has been coated with an oligopeptide, e.g., a hydrophobic polypeptide, or a polymyxin, preferably polymyxin B, thereby to have such oligopeptide, e.g., a hydrophobic polypeptide, or a polymyxin, preferably polymyxin B, stably bound thereto, whereby LPS pyrogens are adhered to the filter.

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