C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/75 (2006.01) A61K 31/165 (2006.01) A61K 31/4045 (2006.01) A61K 31/44 (2006.01) A61K 31/4406 (2006.01) A61P 9/00 (2006.01) C07C 237/08 (2006.01) C07D 209/08 (2006.01) C07D 213/56 (2006.01)
Patent
CA 2695461
The present invention relates to acyclic amino amides of formula (I). These compounds are renin inhibitors of a non-peptidic nature and of low molecular weight. The invention further relates to processes for the preparation of these compounds, pharmaceutical compositions containing them, as well as their use and method of treatment of cardiovascular events and renal insufficiency.
La présente invention concerne des amides aminés acycliques de formule (I). Ces composés sont des inhibiteurs de la rénine de nature non peptidique et de faible poids moléculaire. L'invention concerne en outre des procédés permettant la préparation de ces composés, de compositions pharmaceutiques les contenant, ainsi que leur utilisation et une méthode de traitement d'événements cardio-vasculaires et d'insuffisance rénale.
Chen Austin
Dube Daniel
Mckay Daniel J.
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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