Renin inhibitors and method of use thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 309/04 (2006.01) A61K 31/27 (2006.01) A61K 31/351 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01) A61P 25/22 (2006.01) A61P 25/28 (2006.01) A61P 27/06 (2006.01) C07C 271/16 (2006.01)

Patent

CA 2727987

Disclosed are aspartic protease inhibitors represented by the following Formula: wherein R1 , R2, R3, R4, R5, R6, R7a, R7b and n are as defined herein, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods for treating an aspartic protease mediated disorder using the same.

La présente invention concerne, d'une part des inhibiteurs de protéase aspartique représentés par la formule suivante, ou certains de ses sels pharmaceutiquement admis, et d'autre part des compositions pharmaceutique les contenant et des procédés permettant d'utiliser ces agents pour traiter un trouble imputable à une médiation d'une protéase aspartique. Dans cette formule, R1 , R2, R3, R4, R5, R6, R7a, R7b et n sont tels que définis dans les spécifications.

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