Renin inhibitors containing 5-amino-2,5-disubstituted-...

Details Renin inhibitors containing 5-amino-2,5-disubstituted-... Renin inhibitors containing 5-amino-2,5-disubstituted-...

C - Chemistry, Metallurgy

07

K

530/5.04, 167/10

C07K 5/06 (2006.01) C07C 271/22 (2006.01) C07D 207/16 (2006.01) C07D 217/06 (2006.01) C07D 307/33 (2006.01) C07D 405/12 (2006.01) C07K 5/02 (2006.01)

Patent

CA 1294736

PATENT DPC 6932A 4680-390 RENIN INHIBITORS CONTAINING 5-AMINO-2,5- DISUBSTITUTED-4-HYDROXYPENTANOIC ACID RESIDUES Abstract A series of novel polypeptide dexivatives, con- taining 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these compounds are certain other 5-amino-2,5-disubstituted- 4-hydroxypentanoic acid derivatives.

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