Renin inhibitors containing c-terminal dihydroxy amides

Details Renin inhibitors containing c-terminal dihydroxy amides Renin inhibitors containing c-terminal dihydroxy amides

C - Chemistry, Metallurgy

07

D

150/11, 530/5.04

C07D 309/12 (2006.01) A61K 38/05 (2006.01) C07C 215/20 (2006.01) C07C 215/26 (2006.01) C07C 271/16 (2006.01) C07D 207/34 (2006.01) C07D 339/08 (2006.01) C07D 409/12 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2006839

ABSTRACT OF THE DISCLOSURE The invention concerns novel renin-inhibitory peptides which are useful for treating renin- associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma and diseases caused by retroviruses. Process for preparing the peptides novel intermediates in the processes, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin- associated hypertension, or hyperaldosteronism.

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